MEP latency shift after implantation of deep brain stimulation systems in the subthalamic nucleus in patients with advanced Parkinson's disease
Identifieur interne : 003350 ( Main/Exploration ); précédent : 003349; suivant : 003351MEP latency shift after implantation of deep brain stimulation systems in the subthalamic nucleus in patients with advanced Parkinson's disease
Auteurs : Ute Hidding [Allemagne] ; Tobias B Umer [Allemagne] ; Hartwig Roman Siebner [Allemagne] ; Cüneyt Demiralay [Allemagne] ; Carsten Buhmann [Allemagne] ; Thomas Weyh [Allemagne] ; Christian Moll [Allemagne] ; Wolfgang Hamel [Allemagne] ; Alexander Münchau [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-09.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Advanced stage, Aged, Deep Brain Stimulation, Deep brain stimulation, Electrodes, Implanted, Electromyography, Evoked Potentials, Motor (physiology), Female, Human, Humans, Male, Middle Aged, Motor Cortex (physiopathology), Motor Neurons (physiology), Nervous system diseases, Parkinson Disease (physiopathology), Parkinson Disease (rehabilitation), Parkinson disease, Parkinson's disease, Prospective Studies, Pyramidal Tracts (physiopathology), Reaction Time (physiology), Sensory Thresholds (physiology), Subthalamic Nucleus (physiopathology), Subthalamic nucleus, deep brain stimulation, subthalamic nucleus, transcranial magnetic stimulation.
- MESH :
- physiology : Evoked Potentials, Motor, Motor Neurons, Reaction Time, Sensory Thresholds.
- physiopathology : Motor Cortex, Parkinson Disease, Pyramidal Tracts, Subthalamic Nucleus.
- rehabilitation : Parkinson Disease.
- Aged, Deep Brain Stimulation, Electrodes, Implanted, Electromyography, Female, Humans, Male, Middle Aged, Prospective Studies.
Abstract
Deep brain stimulation (DBS) into the subthalamic nucleus (STN) is a highly effective treatment for advanced Parkinson's disease (PD). The consequences of STN stimulation on intracortical and corticospinal excitability have been addressed in a few studies using transcranial magnetic stimulation (TMS). Although excitability measurements were compared between the STN stimulation OFF and ON condition, in these experiments, there are no longitudinal studies examining the impact of electrode implantation per se on motor excitability. Here, we explored the effects of STN electrode implantation on resting motor thresholds (RMT), motor evoked potential (MEP) recruitment curves, and MEP onset latencies on 2 consecutive days before and shortly after STN surgery with the stimulator switched off, thus avoiding the effects of chronic DBS on the motor system, in 8 PD patients not taking any dopaminergic medication. After surgery, RMT and MEP recruitment curves were unchanged. In contrast, MEP onset latencies were significantly shorter when examined in relaxed muscles but were unchanged under preactivation. We hypothesize that postoperatively TMS pulses induced small currents in scalp leads underneath the TMS coil connecting the external stimulator with STN electrodes leading to inadvertent stimulation of fast‐conducting descending neural elements in the vicinity of the STN, thereby producing submotor threshold descending volleys. These “conditioning” volleys probably preactivated spinal motor neurons leading to earlier suprathreshold activation by the multiple corticospinal volleys produced by TMS of the motor cortex. These TMS effects need to be considered when interpreting results of excitability measurements in PD patients after implantation of STN electrodes. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.20951
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-09">2006-09</date><biblScope unit="vol">21</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1471">1471</biblScope><biblScope unit="page" to="1476">1476</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">C6B3F6A463D22B9150361C22BCC02038F04FC936</idno><idno type="DOI">10.1002/mds.20951</idno><idno type="ArticleID">MDS20951</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Advanced stage</term><term>Aged</term><term>Deep Brain Stimulation</term><term>Deep brain stimulation</term><term>Electrodes, Implanted</term><term>Electromyography</term><term>Evoked Potentials, Motor (physiology)</term><term>Female</term><term>Human</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Cortex (physiopathology)</term><term>Motor Neurons (physiology)</term><term>Nervous system diseases</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (rehabilitation)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Prospective Studies</term><term>Pyramidal Tracts (physiopathology)</term><term>Reaction Time (physiology)</term><term>Sensory Thresholds (physiology)</term><term>Subthalamic Nucleus (physiopathology)</term><term>Subthalamic nucleus</term><term>deep brain stimulation</term><term>subthalamic nucleus</term><term>transcranial magnetic stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Evoked Potentials, Motor</term><term>Motor Neurons</term><term>Reaction Time</term><term>Sensory Thresholds</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Motor Cortex</term><term>Parkinson Disease</term><term>Pyramidal Tracts</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="rehabilitation" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Deep Brain Stimulation</term><term>Electrodes, Implanted</term><term>Electromyography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Homme</term><term>Noyau sousthalamique</term><term>Parkinson maladie</term><term>Stade avancé</term><term>Stimulation cérébrale profonde</term><term>Système nerveux pathologie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deep brain stimulation (DBS) into the subthalamic nucleus (STN) is a highly effective treatment for advanced Parkinson's disease (PD). The consequences of STN stimulation on intracortical and corticospinal excitability have been addressed in a few studies using transcranial magnetic stimulation (TMS). Although excitability measurements were compared between the STN stimulation OFF and ON condition, in these experiments, there are no longitudinal studies examining the impact of electrode implantation per se on motor excitability. Here, we explored the effects of STN electrode implantation on resting motor thresholds (RMT), motor evoked potential (MEP) recruitment curves, and MEP onset latencies on 2 consecutive days before and shortly after STN surgery with the stimulator switched off, thus avoiding the effects of chronic DBS on the motor system, in 8 PD patients not taking any dopaminergic medication. After surgery, RMT and MEP recruitment curves were unchanged. In contrast, MEP onset latencies were significantly shorter when examined in relaxed muscles but were unchanged under preactivation. We hypothesize that postoperatively TMS pulses induced small currents in scalp leads underneath the TMS coil connecting the external stimulator with STN electrodes leading to inadvertent stimulation of fast‐conducting descending neural elements in the vicinity of the STN, thereby producing submotor threshold descending volleys. These “conditioning” volleys probably preactivated spinal motor neurons leading to earlier suprathreshold activation by the multiple corticospinal volleys produced by TMS of the motor cortex. These TMS effects need to be considered when interpreting results of excitability measurements in PD patients after implantation of STN electrodes. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li><li>Schleswig-Holstein</li></region><settlement><li>Kiel</li><li>Munich</li></settlement></list><tree><country name="Allemagne"><noRegion><name sortKey="Hidding, Ute" sort="Hidding, Ute" uniqKey="Hidding U" first="Ute" last="Hidding">Ute Hidding</name></noRegion><name sortKey="B Umer, Tobias" sort="B Umer, Tobias" uniqKey="B Umer T" first="Tobias" last="B Umer">Tobias B Umer</name><name sortKey="Buhmann, Carsten" sort="Buhmann, Carsten" uniqKey="Buhmann C" first="Carsten" last="Buhmann">Carsten Buhmann</name><name sortKey="Demiralay, Cuneyt" sort="Demiralay, Cuneyt" uniqKey="Demiralay C" first="Cüneyt" last="Demiralay">Cüneyt Demiralay</name><name sortKey="Hamel, Wolfgang" sort="Hamel, Wolfgang" uniqKey="Hamel W" first="Wolfgang" last="Hamel">Wolfgang Hamel</name><name sortKey="Moll, Christian" sort="Moll, Christian" uniqKey="Moll C" first="Christian" last="Moll">Christian Moll</name><name sortKey="Munchau, Alexander" sort="Munchau, Alexander" uniqKey="Munchau A" first="Alexander" last="Münchau">Alexander Münchau</name><name sortKey="Siebner, Hartwig Roman" sort="Siebner, Hartwig Roman" uniqKey="Siebner H" first="Hartwig Roman" last="Siebner">Hartwig Roman Siebner</name><name sortKey="Siebner, Hartwig Roman" sort="Siebner, Hartwig Roman" uniqKey="Siebner H" first="Hartwig Roman" last="Siebner">Hartwig Roman Siebner</name><name sortKey="Weyh, Thomas" sort="Weyh, Thomas" uniqKey="Weyh T" first="Thomas" last="Weyh">Thomas Weyh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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